This Smart News Release features multimedia. View the full release here: http://www.businesswire.com/news/home/20161215005641/en/ Cancer Research UKs Centre for Drug Development (CDD) will sponsor and fund a Phase Ia and Phase Ib clinical trial for a drug called BT1718, a Bicycle Drug ConjugateTM (BDC) being developed by Bicycle Therapeutics, in patients with advanced solid tumours. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MTP), which is highly expressed in many solid tumours, including triple negative breast cancer and non-small cell lung cancer. Dr. Udai Banaji, Principal Investigator for the Phase I trial, said: Im very excited to be involved in the first clinical study of BT1718. Based on the impressive pre-clinical data, I look forward to evaluating the clinical utility of BT1718, the first of a new class of agents that specifically targets tumour cells using a bicyclic peptide linked to an anticancer agent. The trial will be co-managed by Cancer Research UK and Bicycle Therapeutics.
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